Sarah and her brother have grown up next to the world’s largest garbage dump on Staten Island in New York City. Little do they know, thousands of rodents at the dump have mutated into gruesome, killer rats and one of the workers there has just been badly mauled. Without mercy, the rats wreak havoc and devistation upon the once-peaceful neighborhood, entering homes through kitchen sinks and toilets. Now the entire city stands on the brink of total infestation. Can the kids save millions of innocent people from the approaching and unrelenting rat horde?